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2021

Waybright JM, Clinkscales SE, Barnash KD, Budziszewski GR, Rectenwald JM, Chiarella AM, Norris-Drouin JL, Cholensky SH, Pearce KH, Herring LE, McGinty RK, Hathaway NA, James LI. A Peptidomimetic Ligand Targeting the Chromodomain of MPP8 Reveals HRP2’s Association with the HUSH Complex. ACS Chem Biol. 2021 Sep 17;16(9):1721-1736. doi: 10.1021/acschembio.1c00429.

 

 

McGinty RK, Tan S. Principles of nucleosome recognition by chromatin factors and enzymes. Curr Opin Struct Biol. 2021 Jun 28;71:16-26. doi: 10.1016/j.sbi.2021.05.006.

 

 

2020

Boyer JA, Spangler CJ, Strauss JD, Cesmat AP, Liu P, McGinty RK, Zhang Q. Structural basis of nucleosome-dependent cGAS inhibition. Science. 2020 Sep 10;eabd0609. doi: 10.1126/science.abd0609. Online ahead of print

 

 

Skrajna A, Goldfarb D, Kedziora KM, Cousins EM, Grant GD, Spangler CJ, Barbour EH, Yan X, Hathaway NA, Brown NG, Cook JG, Major MB, McGinty RK. Comprehensive nucleosome interactome screen establishes fundamental principles of nucleosome binding. Nucleic Acids Res. 2020 (https://doi.org/10.1093/nar/gkaa544)

 

2019

Anderson CJ, Baird MR, Hsu A, Barbour EH, Koyama Y, Borgnia MJ, McGinty RK. Structural Basis for Recognition of Ubiquitylated Nucleosome by Dot1L Methyltransferase. Cell Reports. 2019 Feb 12;26(7):1681-1690.

2018

Jeon J, McGinty RK, Muir TW, Kim JA, Kim J. Crosstalk among Set1 complex subunits involved in H2B ubiquitylation-dependent H3K4 methylation. Nucleic Acids Res. 2018 Nov 30;46(21):11129-11143.

Prior to joining UNC

2016

McGinty RK, Makde RD, Tan S. Preparation, Crystallization, and Structure Determination of Chromatin Enzyme/Nucleosome Complexes. Methods Enzymol. 2016;573:43-65.

Girish TS, McGinty RK, Tan S. Multivalent Interactions by the Set8 Histone Methyltransferase With Its Nucleosome Substrate. J Mol Biol. 2016 Apr 24;428(8):1531-43.

McGinty RK, Tan S. Recognition of the nucleosome by chromatin factors and enzymes. Curr Opin Struct Biol. 2016 Apr;37:54-61.

2015

McGinty RK, Tan S. Nucleosome structure and function. Chem Rev. 2015 Mar 25;115(6):2255-73.

 

2014

McGinty RK, Henrici RC, Tan S. Crystal structure of the PRC1 ubiquitylation module bound to the nucleosome. Nature. 2014 Oct 30;514(7524):591-6.

 

2013

Tang Z, Chen WY, Shimada M, Nguyen UT, Kim J, Sun XJ, Sengoku T, McGinty RK, Fernandez JP, Muir TW, Roeder RG. SET1 and p300 act synergistically, through coupled histone modifications, in transcriptional activation by p53. Cell. 2013 Jul 18;154(2):297-310.

 

Kim J, Kim JA, McGinty RK, Nguyen UT, Muir TW, Allis CD, Roeder RG. The n-SET domain of Set1 regulates H2B ubiquitylation-dependent H3K4 methylation. Mol Cell. 2013 Mar 28;49(6):1121-33.

 

McGinty RK, and Tan S. Histone, nucleosome, and chromatin structure. Fundamentals of Chromatin. 2013 J. L. Workman and S. M. Abmayr, eds. New York: Springer, pp. 1–28.


2012

Whitcomb SJ, Fierz B, McGinty RK, Holt M, Ito T, Muir TW, Allis CD. Histone monoubiquitylation position determines specificity and direction of enzymatic cross-talk with histone methyltransferases Dot1L and PRC2. J Biol Chem. 2012 Jul 6;287(28):23718-25.


2011

Ruthenburg AJ, Li H, Milne TA, Dewell S, McGinty RK, Yuen M, Ueberheide B, Dou Y, Muir TW, Patel DJ, Allis CD. Recognition of a mononucleosomal histone modification pattern by BPTF via multivalent interactions. Cell. 2011 May 27;145(5):692-706.

 

Fierz B, Chatterjee C, McGinty RK, Bar-Dagan M, Raleigh DP, Muir TW. Histone H2B ubiquitylation disrupts local and higher-order chromatin compaction. Nat Chem Biol. 2011 Feb;7(2):113-9.


2010

Scheuermann JC, de Ayala Alonso AG, Oktaba K, Ly-Hartig N, McGinty RK, Fraterman S, Wilm M, Muir TW, Müller J. Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB. Nature. 2010 May 13;465(7295):243-7.

 

Chatterjee C, McGinty RK, Fierz B, Muir TW. Disulfide-directed histone ubiquitylation reveals plasticity in hDot1L activation. Nat Chem Biol. 2010 Apr;6(4):267-9.


2009

McGinty RK, Köhn M, Chatterjee C, Chiang KP, Pratt MR, Muir TW. Structure-activity analysis of semisynthetic nucleosomes: mechanistic insights into the stimulation of Dot1L by ubiquitylated histone H2B. ACS Chem Biol. 2009 Nov 20;4(11):958-68.

 

McGinty RK, Chatterjee C, Muir TW. Semisynthesis of ubiquitylated proteins. Methods Enzymol. 2009;462:225-43.

 

Chiang KP, Jensen MS, McGinty RK, Muir TW. A semisynthetic strategy to generate phosphorylated and acetylated histone H2B. Chembiochem. 2009 Sep 4;10(13):2182-7.

 

Kim J, Guermah M, McGinty RK, Lee JS, Tang Z, Milne TA, Shilatifard A, Muir TW, Roeder RG. RAD6-Mediated transcription-coupled H2B ubiquitylation directly stimulates H3K4 methylation in human cells. Cell. 2009 May 1;137(3):459-71.


2008

McGinty RK, Kim J, Chatterjee C, Roeder RG, Muir TW. Chemically ubiquitylated histone H2B stimulates hDot1L-mediated intranucleosomal methylation. Nature. 2008 Jun 5;453(7196):812-6.


2007

Chatterjee C, McGinty RK, Pellois JP, Muir TW. Auxiliary-mediated site-specific peptide ubiquitylation. Angew Chem Int Ed Engl. 2007;46(16):2814-8.